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Elongated half-life of p53 protein in Ampkα1-deficient MEFs. A, PCR results of mRNA expression levels of p53 in wild-type and Ampkα1−/− MEFs. B, p53 levels in wild-type MEFs treated with cycloheximide (CHX, 50 μg/ml) for the indicated times. C, Ampkα1−/− MEFs were treated with cycloheximide (50 μg/ml) for the indicated times, and p53 levels were detected with Western blot. D and E, quantitative analysis of the half-life of p53 in wild-type and Ampkα1−/− MEFs. Ctrl, control.
