Skip to main content
. 2012 Jan 20;287(11):8154–8162. doi: 10.1074/jbc.M111.308601

FIGURE 2.

FIGURE 2.

Alterations in age-dependent motor function, working memory, and anxiety in TBA42 mice. The behavioral phenotype of TBA42 mice was assessed at 3, 6, and 12 months (M) of age. TBA42 mice demonstrated significantly reduced performance in the balance beam (A) and the cross-maze tasks (B) at the age of 12 months. There was no difference in the number of arm entries in the cross-maze task between TBA42 and wild-type control (C). The elevated plus maze revealed that TBA42 mice already had highly reduced anxiety levels by the age of 3 months (D) (two-way ANOVA with Bonferroni post hoc tests; *, p < 0.05; **, p < 0.01; ***, p < 0.001; n = 6–12 per group).