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Aggravated behavioral impairments in FAD42 mice. Motor function and anxiety were assessed in 6-month-old WT, 5XFAD, TBA42, and FAD42 mice using the balance beam (A) and elevated plus maze (B), respectively. In both tasks, transgenic FAD42 mice showed increased impairment relative to the WT and single transgenic 5XFAD and TBA42 animals (one-way ANOVA with Bonferroni post hoc tests). ***, p < 0.001 (n = 5–9 per group).
