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. 2012 Jan 20;287(11):8154–8162. doi: 10.1074/jbc.M111.308601

FIGURE 6.

FIGURE 6.

Increased levels of AβpE3 in the brains of FAD42 mice as shown by ELISA. 5XFAD and FAD42 mice demonstrated elevated Aβx–42 levels in the TBS- (A) and SDS-soluble (C) fraction compared with TBA42 mice. There was no significant difference between the Aβx–42 levels in 5XFAD and FAD42 mice for either fraction. In all mouse lines, the SDS soluble fraction of Aβx–42 harbored the most Aβ peptides. The levels of TBS-soluble AβpE3–x were significantly higher in FAD42 mice compared with TBA42 mice (B). Substantially more SDS-soluble AβpE3–x was detected in FAD42 mice relative to both 5XFAD and TBA42 mice (D) (one-way ANOVA and unpaired t tests). *, p < 0.05; **, p < 0.01; ***, p < 0.001.