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. 2001 Apr 24;98(9):5199–5204. doi: 10.1073/pnas.091056898

Figure 2.

Figure 2

Disease-modifying effects of RANTES haplotypes in seroconverting European Americans. (a and b) The Kaplan–Meier (KM) curves of the development of AIDS or death in the seroconverting European American portion of the cohort that lack (blue curve) or possess (red curve) the most common RANTES GC haplotype. Notably, most individuals who lack the GC haplotype have the haplotype pair AC/AC (Fig. 1c), and for this reason the pattern of the blue KM curves in a and b is very similar to those of the blue KM curve for AC/AC in c and d. P and RH [95% CI (confidence limits)] indicate the significance value by log-rank test and the relative hazard with respect to the reference group, respectively. (c and d) KM curves comparing the clinical course of seroconverting European Americans with the following haplotype pairs: GC/GC (red); AC/GC (green); GC/AG (black line); and AC/AC (blue). The reference group for the survival analyses is individuals that are homozygous for the ancestral RANTES haplotype AC.