FIGURE 8.

Scheme indicating residues and domains involved in intersubunit interactions within eIF2B complexes. The conserved domains are indicated. Numbering is on the basis of the human protein sequences. A, domains and residues involved in interactions in eIF2Bϵ with other eIF2B subunits. The minimum region required for interaction with the “regulatory” subcomplex is shown in red, along with mutations affecting this interaction. The minimum region required for interaction with eIF2Bγ is shown in green, along with mutations identified as affecting this interaction. B, domains and residues involved in interactions of eIF2Bγ with other eIF2B subunits. The minimum region required for the interaction of eIF2Bγ with the other eIF2B subunits is shown in red, along with mutations of residues affecting these interactions.