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Generation of RasGRP4−/− mice. A, targeting strategy. Exons 2 to 4 were replaced by the PGK neo cassette. B, absence of RasGRP4 protein. Postnuclear lysates from thymocytes, splenocytes, and bone marrow cells from RasGRP4−/− (4KO) and WT mice were analyzed by Western blotting with anti-RasGRP4 anti-serum. An arrow indicates where RasGRP4 protein migrated.
