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Chp1 is essential for SL-1 biosynthesis, and Sap modulates SL-1 levels. M. tuberculosis wild-type, Δsap, Δchp1, ΔmmpL8, and corresponding complemented strains were metabolically labeled with [14C]propionate. Cell pellet extracts were analyzed by TLC and phosphorimaging. SL-1 was observed at reduced levels in Δsap and not at all in Δchp1 and ΔmmpL8, and all three strains accumulated SL1278. The wild-type lipid profile was restored by complementation for all strains.
