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THL treatment specifically inhibits conversion of SL1278 to SL-1. Upper panel, lipid extracts from M. tuberculosis treated with different concentrations of THL for 6 h followed by [14C]propionate labeling reveal the dose-dependent but incomplete inhibition of SL-1 formation and the accumulation of SL1278 by TLC and phosphorimaging. Lower panel, phthiocerol dimycocerosate (PDIM) loading control.
