Figure 2.
Disruption of the Cyp 4a14 gene raises systemic blood pressures in a sexually dimorphic fashion: the blood pressures of conscious adult (10- to 14-week-old) male and female mice were measured by means of a right carotid artery catheter. Shown are averages ± SE calculated from groups of 40 (−/−), 38 (+/+), or 12 (+/−) male mice (Top frame, A) or from groups of 20 (−/−) or 14 (+/+) female mice (Bottom frame, B). [Pressure differentials between Cyp 4a14(+/+) and (−/−) mice were of 38, 30, and 25 mm and of 14, 17, and 11 mm Hg, for mean, systolic, and diastolic blood pressures, and for male and female mice, respectively]. (A) Significantly different from the male wild type: *, Cyp (+/−), P ≤ 0.007; **, Cyp (−/−), P ≤ 1 × 10−5. (B) Significantly different from the female wild type: *, Cyp (−/−), P ≤ 1 × 10−4. No significant pressure differences were observed between female Cyp 4a14 (+/−) and 4a14 (+/+) mice. See Methods for details.