Table 1.
Descriptions of Screening Strategies Evaluated in the Cost-Effectiveness Models*
| Screening Strategy |
Description |
|---|---|
| No screening | No screening for prevention; treatment only if an osteoporotic fracture occurs |
| DXA −2.5 | DXA of the femoral neck and lumbar spine, with treatment if the T-score is −2.5 or less at either site |
| DXA −2.0 | DXA of the femoral neck and lumbar spine, with treatment if the T-score is −2.0 or less |
| DXA −1.5 | DXA of the femoral neck and lumbar spine, with treatment if the T-score is −1.5 or less |
| QUS −1.0 | Calcaneal QUS prescreening, with subsequent DXA screening if the QUS T-score is −1.0 or less and with treatment if the DXA T-score is −2.5 or less |
| QUS −0.5 | Calcaneal QUS prescreening, with DXA screening if the QUS T-score is −0.5 or less and with treatment if the DXA T-score is −2.5 or less |
| SCORE −2.5 | SCORE tool prescreening, with DXA screening if the SCORE result is 7 or greater and with treatment if the DXA T-score is −2.5 or less |
| SCORE NOF | SCORE prescreening, with DXA screening if the SCORE result is 7 or greater and with treatment if the DXA T-score is −2.0 or less; or DXA T-score −1.5 or less with an additional osteoporosis risk factor; or age ≥ 80 |
DXA = dual-energy x-ray absorptiometry; NOF = National Osteoporosis Foundation; QUS = quantitative ultrasonography; SCORE = Simple Calculated Osteoporosis Risk Estimation.
*
Each strategy was evaluated for initiation in postmenopausal women with no known history of osteoporotic fracture at 6 different ages (55, 60, 65, 70, 75, and 80 years of age) and with 3 different repeat screening intervals (1-time screening, rescreening every 5 years, or rescreening every 10 years).