Fig. 2.

Histology of NEP25 mice treated with ARB, MRB or both. NEP25 mouse, a model of specific podocyte damage, showed extensive glomerulosclerosis, an increased area positive for collagen IV (Col IV) and a decreased number of WT1-positive podocytes in the glomerulus. Treatment with the ARB losartan, the MRB spironolactone, or with both in combination attenuated podocyte damage-induced glomerulosclerosis, collagen deposition and podocyte loss.