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. Author manuscript; available in PMC: 2012 Apr 4.
Published in final edited form as: Mol Cancer Ther. 2010 Sep 3;9(11):3065–3073. doi: 10.1158/1535-7163.MCT-10-0623

Figure 8. Schematic representation of a generic FRET based biosensor for tyrosine kinases and their inhibitors in human cancers.

Figure 8

Adapted from Picchu, a platform of tyrosine kinase specific FRET cassettes can be generated by replacing pTyr221 and Crk SH2 domain as indicated.