Table I.

A: The proportion of infants with an adequate functional response following 23vPPV immunization
	OPAa		AIb
Number of serotypes	2 weeks	5 months	2 weeks	5 months
0	100%	100%		100%
1	98%	91%		98%
2	89%	76%	100%	91%
3	84%	53%	94%	78%
4	71%	20%	89%	70%
5	35%	7%	83%	65%
6	22%	5%	69%	50%
7	11%	5%	63%	43%
8	2%	4%	52%	35%
9			35%	20%
10			31%	19%
11			24%	17%
12			19%	15%
13			13%	15%
14			13%	13%
15			13%	11%
16			7%	9%
17			6%	7%
21			4%	4%
22			2%	2%

B: The proportion of infants with an adequate functional response to epidemiologically relevant serotypes following 23vPPV immunizationa
	OPA response (%)b		Avidity response (%)c
Serotype	2 weeks post	5 months post	2 weeks post	5 months post
1	29*	11	11	9
5	77*	46*	15	11
6B	14	16	21	13
14	27	27	21	18
19F	NTd	NT	25	22
23F	38	21	19	13

^aOPA - adequate response is defined as an OPA titre ≥ 8 (n=55) to 8 serotypes tested.

^bAI - adequate response defined as AI ≥ 50% (n=53) to 23 serotypes tested

^abased on data published by PneumoADIP;

^bdefined as OI ≥ 8;

^cdefined as MAI ≥ 50%;

^dNT = not tested;

^*p<0.01 compared to pre-immunization (n=56)