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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Exp Neurol. 2011 Nov 4;244:36–42. doi: 10.1016/j.expneurol.2011.10.028

Figure 1.

Figure 1

Finasteride increased frequency of spontaneous seizures in epileptic animals. A: Administration of 100 mg/kg finasteride, a 5α reductase enzyme blocker, increased the frequency of spontaneous seizures in female epileptic animals (n=11). Increased seizure frequency returned to baseline 16–18 hrs after finasteride administration (inset) (modified from Lawrence et al, 2010). B: Treatment with finasteride (100 mg/kg) also increased frequency of spontaneous seizures in male epileptic animals (n=4). The seizures returned to baseline frequency 4–5 hrs after finasteride treatment (inset).