Table 1.

Standard thermodynamic profiles for 5-HO-dC (X) modified DNA at pH 7.0 in 10 mM sodium phosphate buffer.

ODN	Sequence	NaCl (mM)	TM (°C)	ΔH (kcal/mol)	ΔG° (kcal/mol)	TΔS (kcal/mol)	ΔNNa+ (mol-1 DNA)	Δnw (mol-1DNA)
1	CGCGAATTCGCG GCGCTTAAGCGC	10	33.3	−116.0	−6.9	−109.0	−2.3 ± 0.15	−38.0 ± 2.0
2	CGCGAATTXGCG GCGXTTAAGCGC	10	31.5	−74.3	−2.8	−71.5	−1.0 ± 0.11	−21.0 ± 3.0
3	GAGAGCGCTCTC CTCTCGCGAGAG	10	41.3	−78.2	−6.9	−71.3	−3.4 ± 0.2	−41.0 ± 3.0
4	GAGAGCGCTXTC CTXTCGCGAGAG	10	15.0	−41.7	−0.7	−41.0	−2.3 ± 0.15	−13.0 ± 1.0
5	GACAGCGCTCTC CTCTCGCGACAG	10	8.5	−31.1	+0.2	−31.3	n.d.	n.d.

^aOligomer concentration = 10 μM