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. Author manuscript; available in PMC: 2012 Apr 4.
Published in final edited form as: Gastroenterology. 2008 Jan 11;134(4):1017–1027. doi: 10.1053/j.gastro.2008.01.008

Figure 7.

Figure 7

HLA-A2+ epithelial cells are target of pA2-induced CD8+ T-cell activation. (A and B) The epithelial cell lines Caco2 (A2+) and HT29 (A2–) were used as APC (1 × 105) to stimulate pA2-specific CD8+ T cells (0.3 × 105). Levels of IFN-γ and GrB were evaluated in cell supernatants following 48 hours of incubation. (C) Basal level of HLA-A2 expressed on cell's surface of APCs (JY and Caco2). (D) Apoptosis of epithelial cells (gated in R2) and CD25 expression on T cells (gated in R1) were analyzed in coculture experiments.