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. Author manuscript; available in PMC: 2012 Apr 4.
Published in final edited form as: Behav Brain Res. 2010 Mar 1;210(2):288–291. doi: 10.1016/j.bbr.2010.02.043

Fig. 2.

Fig. 2

Fig. 2

Effect of the CRF receptor antagonist D-Phe CRF(12-41) (control, n = 20; alcohol, n = 16) on the elevations in brain reward thresholds (A) and increased response latencies (B) associated with alcohol withdrawal. Brain reward thresholds and response latencies are expressed as a percentage of the pretest day values. Crosses (# P<0.05, ## P<0.01) indicate elevations in brain reward thresholds or increased response latencies compared to those of the corresponding control group. Plus signs (+ P<0.05, ++ P<0.01) indicate lower brain reward thresholds compared to those of rats withdrawing from alcohol and acutely treated with vehicle. Asterisks (** P<0.01) indicate lower brain reward thresholds compared to those of rats withdrawing from alcohol and acutely treated with 10 μg of D-Phe CRF(12-41).