Skip to main content
. Author manuscript; available in PMC: 2012 Apr 4.
Published in final edited form as: Neuromolecular Med. 2009 Oct 17;12(1):48–55. doi: 10.1007/s12017-009-8097-7

Figure 4. Inhibitory Hippocampal Remodeling and Increased Inhibition in hAPPJ20 Mice.

Figure 4

hAPPJ20 mice show robust remodeling of inhibitory circuits in the dentate gyrus, a brain region critically involved in learning and memory. A) Compared with NTG controls (top), hAPPJ20 mice (bottom) had increased NPY/GABAergic axons in the molecular layer and ectopic expression of NPY in mossy fibers. B) Diagram depicting axonal remodeling in hAPPJ20 mice, including GABAergic sprouting (green) onto granule cells (grey) and sprouting of NPY-positive mossy fibers (orange) onto basket cells (blue). C) Enhanced inhibitory input (mIPCS) onto granule cells in hAPPJ20 mice. Adapted from (Palop et al., 2007).