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. Author manuscript; available in PMC: 2012 Aug 15.
Published in final edited form as: Biochem J. 2011 Aug 15;438(1):33–37. doi: 10.1042/BJ20110009

Figure 3. Gastrin induces ABCB1 through its promoter activation.

Figure 3

(A) Caco-2 cells were incubated with different concentration of gastrin as indicated in figure. (B) Caco-2 cells were incubated with gastrin (1 μM) in the presence or absence of YM022 (10 μM), and mRNA level for ABCB1 was analyzed by RT-qPCR. (C) AGS-E cells were transfected with -1923 ABCB1 reporter, and then gastrin (1 μM) was added to the cells in the presence or absence of YM022. Luciferase activities were normalized to β-gal activity. Data are mean ± SEM, n=3 for three separate experiments. *p-value < 0.05. GAS, gastrin.