Skip to main content
. Author manuscript; available in PMC: 2012 Aug 15.
Published in final edited form as: Biochem J. 2011 Aug 15;438(1):33–37. doi: 10.1042/BJ20110009

Figure 5. PTC decreases rhodamine 123 accumulation and is a substrate of ABCB1.

Figure 5

(A) PTC-treated cells were exposed with rhodamine 123 for 1 h, and fluorescence intensity in cell lysates was analyzed by microplate reader. (B) Cells were incubated with UIC2 antibody in the presence and absence (filled histogram) of PTC (thick line) or VIN (dotted line) as described in Materials and Methods. UIC2 reactivity for ABCB1 was analyzed by flow cytometry. Rh123, rhodamine 123; Con, control; VIN, vinblastine.