Table 1.
SAMe REVERSED DDC INDUCED EPIGENETIC CHANGES
| Histone Modification | Residue | DDC Refed | DDC refed + SAMe |
|---|---|---|---|
|
| |||
| Acetylation | Histone 3 lysine 9 (AcH3K9) | ↑ | ↑ |
|
| |||
| Histone 3 lysine 18 (AcH3K18) | ↓ | ↓ | |
|
| |||
| Trimethylation | Histone 3 lysine 4 (H3K4me3) | ↓ | nl |
|
| |||
| Histone 3 lysine 9 (H3K9me3) | ↓ | nl | |
|
| |||
| Ubiquitinylation | H2A / H2B | ↑ | nl |
|
| |||
| Histone Modifying Enzyme | Enzyme | DDC Refed | DDC refed + SAMe |
|
| |||
| Histone Acetyl Transferase | GCN5 | ↑ | nl |
|
| |||
| Pcaf | ↓ | ||
|
| |||
| Cbp/p300 | ↓ | ||
|
| |||
| Histone Deacetylase | Sirtuin 1 | ↓ | ↓ |
|
| |||
| HDAC9 | ↑ | ↓ | |
|
| |||
| HDAC7a | ↑ | nl | |
|
| |||
| HDAC11 | ↓ | ||
|
| |||
| Histone Methyltransferase | SET 7/9 | ↑ | nl |
|
| |||
| SUV 39H1 | ↓ | nl | |
|
| |||
| Histone Demethylase | LSD1 | nl | nl |