Skip to main content
. Author manuscript; available in PMC: 2012 May 26.
Published in final edited form as: J Med Chem. 2011 Apr 26;54(10):3549–3563. doi: 10.1021/jm2000882

Figure 1.

Figure 1

Left. Model of pYLPQ-NHBn34 docked to the SH2 domain of Stat3 showing space between inhibitor and Glu638. Surface electrostatic potential was calculated with APBS tools in PyMol.65 Right. Incorporation of methyl group on the β-position of 4-phosphoryloxycinnamide enhances affinity for Stat3, as judged by a fluorescence polarization assay. 4a and 7a were from reference 29. 5a was from reference 30.