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The effect of E2 on ATP-induced [Ca2+]i transients in estrogen receptor-α knockout (ERαKO) and estrogen receptor-β knockout (ERβKO) mice. (a) In ERαKO mouse, E2 added for 5 min didn’t inhibit ATP-induced [Ca2+]i transient; (b) In ERβKO mouse E2 stimulation significantly attenuated the ATP-stimulated [Ca2+]i transient similar to that observed in Wt mouse. Summary data represented on the right bar graphs. *Statistically significant difference from control, P<0.05.
