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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Protein Expr Purif. 2012 Feb 20;82(2):389–395. doi: 10.1016/j.pep.2012.02.010

Fig. 3.

Fig. 3

Recombinant mPRDC inhibits BMP signaling. (A,B) C2C12 cells stably transfected with a BMP responsive luciferase reporter were treated with BMP2 (left) or BMP4 (right) alone or in pre-incubated with increasing concentrations of mPRDC from either Peak-1 (A) or Peak-2 (B). (C) Recombinant mPRDC does not inhibit activin A signaling. HEK293 response to activin A signaling shows that mPRDC Peak-1 (top) and Peak-2 (bottom) do not interfere with activin A signaling. Percent activity was calculated as percentage of the ligand signal in the absence of mPRDC.