Table 1.

Compounds with high-confidence antiproliferative activity in thyroid cancer cells

Drug	Efficacy	Curve classa	IC50 (μm)
6-Mercaptopurine monohydrate	−66	−1.2	2.11
Acivicin	−62	−2.2	13.34
Adapalene	−122	−2.1	18.84
Alazanini triclofenas	−114	−2.1	21.14
Amsacrine hydrochloride	−120	−2.1	23.72
Anazolenum natricum	−62	−2.2	14.96
a-Solanine	−130	−2.1	26.61
Atorvastatin	−62	−2.2	14.96
Auranofin	−93	−2.3	2.66
Azacitidine	−72	−2.2	13.34
Azathioprine	−61	−1.2	4.22
Benzylhydrochlorothiazide	−115	−2.1	23.72
Bortezomib	−94	−1.1	0.02
Broquinaldol	−93	−2.2	21.14
Bufogenin	−66	−1.2	0.75
C.I. basic violet 14, free base	−65	−2.2	21.14
Cantharidin	−69	−1.2	1.28
Carboquone	−81	−1.1	1.50
Carminomycin	−61	−1.2	0.47
Chlorure de methylrosanilinum	−120	−2.1	21.14
Clofoctol	−104	−2.1	21.14
Compactin	−67	−2.2	6.68
Deslanoside	−65	−1.2	0.13
Deslorelin acetate	−94	−2.1	11.89
Dithiazanine iodide	−122	−2.1	23.72
Ebastine	−126	−2.1	23.72
Floxuridine	−67	−1.2	0.60
Fluvastatina	−68	−1.2	1.19
Gramicidin	−95	−2.2	18.84
Homoharringtonine	−78	−2.2	3.76
Idarubicin hydrochloride	−93	−2.1	0.94
Ivermectin	−119	−2.1	23.72
Lanatoside A	−63	−1.2	0.09
Lanatoside C	−78	−1.2	0.17
Lestaurtinib	−112	−2.1	13.34
Lissamine green B	−77	−2.2	11.89
Lovastatin	−68	−1.2	3.35
Mecetronium ethylsulfate	−101	−2.1	18.84
Mercufenol chloride	−101	−2.1	6.68
Methyl violet	−108	−2.1	16.79
Mibefradil dihydrochloride	−118	−2.1	23.72
Mitomycin C	−93	−2.2	23.72
Mitoxantrone dihydrochloride	−90	−2.2	8.05
Niclosamide	−64	−1.2	0.27
Nitrovin	−93	−2.1	7.50
Nitroxoline	−80	−2.2	13.34
Ouabain	−71	−1.1	0.05
Para−chloromercuriphenol	−98	−2.1	9.44
Phenylmercuric acetate	−99	−1.1	2.66
Phenylmercuric borate	−104	−2.1	9.44
Potassium dichromate	−126	−2.1	21.14
Proflavine hemisulfate	−75	−2.2	21.14
Proscillaridin A	−60	−1.2	0.01
Puromycin hydrochloride	−94	−1.1	5.31
Pyrvinium pamoate	−109	−2.1	9.03
Quinaldine blue	−122	−2.1	26.61
Raloxifene hydrochloride	−121	−2.1	23.72
Rimonabant	−89	−2.2	23.72
Sanguinarine	−91	−2.1	18.84
Simvastatin	−77	−2.2	8.05
Sodium Dichromate Dihydrate	−119	−2.1	23.72
Sorafenib tosylate	−97	−2.2	26.61
Suberoylanilide hydroxamic acid	−65	−2.2	11.89
Tannic acid	−87	−2.2	21.14
Teniposide	−106	−2.1	4.73
Tetradonii bromidum	−83	−2.2	26.61
Thimerosal	−93	−1.1	2.66
Thionosine	−68	−1.2	1.68
Tomatine	−92	−2.1	7.50
Trequinsin hydrochloride	−123	−2.1	26.61
Tribromsalan	−69	−2.2	11.89
Trypan blue	−94	−2.2	10.59
Tyrothricin	−107	−2.1	7.50
Valrubicin	−73	−2.2	16.79
Vandetanib	−70	−2.2	14.96
Vinblastine sulfate	−64	−1.2	0.21
Zinc pyrithione	−91	−1.1	2.37

^aHighest-confidence curve classes (see also Materials and Methods for definition).