Table 3.
Posterior probabilities for pulmonary embolism stratified for age, pretest probability at increasing thresholds for a normal D-dimer
| Adjustment Criteria | Cutoff for an abnormal D-dimer concentration (ng/mL) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 500 | 750 | 1000 | 1250 | 1500 | 5000 | 10000 | 25000 | ||
| Age | 0–29 | 0/12 (0%) | 1/18 (6%) | 1/22 (5%) | 1/23 (4%) | 1/23 (4%) | 8/48 (17%) | 9/51 (18%) | 9/51 (18%) |
| 30–49 | 5/56 (9%) | 8/81 (10%) | 8/88 (9%) | 9/101 (9%) | 10/110 (9%) | 26/169 (15%) | 28/174 (16%) | 28/175 (16%) | |
| 50–69 | 2/69 (3%) | 6/125 (5%) | 8/148 (5%) | 12/187 (6%) | 18/213 (8%) | 58/312 (19%) | 63/323 (20%) | 67/331 (20%) | |
| 70–100 | 1/15 (7%) | 4/34 (12%) | 4/52 (8%) | 6/63 (10%) | 7/77 (9%) | 13/110 (12%) | 18/116 (16%) | 22/121 (18%) | |
| all ages | 8/152 (5%) | 19/258 (7%) | 21/310 (7%) | 28/374 (7%) | 36/423 (9%) | 105/639 (16%) | 118/664 (18%) | 126/678 (19%) | |
| Wells Score | <2 | 3/80 (4%) | 8/139 (6%) | 9/165 (5%) | 10/185 (5%) | 14/212 (7%) | 36/292 (12%) | 38/301 (13%) | 39/304 (13%) |
| 2 to 6 | 3/68 (4%) | 9/113 (8%) | 9/134 (7%) | 15/174 (9%) | 19/196 (10%) | 59/316 (19%) | 68/328 (21%) | 72/336 (21%) | |
| >6 | 2/4 (50%) | 2/6 (33%) | 3/11 (27%) | 3/15 (20%) | 3/15 (20%) | 10/31 (32%) | 12/35 (34%) | 15/38 (39%) | |
| ≤4 | 4/106 (4%) | 11/186 (6%) | 12/221 (5%) | 16/260 (6%) | 21/299 (7%) | 54/434 (12%) | 57/445 (13%) | 60/452 (13%) | |
| Revised Geneva Score |
<4 | 2/65 (3%) | 3/98 (3%) | 3/104 (3%) | 4/116 (3%) | 7/126 (6%) | 18/159 (11%) | 18/160 (11%) | 18/160 (11%) |
| 4 to 10 | 4/75 (5%) | 13/139 (9%) | 14/178 (8%) | 19/220 (9%) | 24/256 (9%) | 64/398 (16%) | 72/413 (17%) | 77/424 (18%) | |
| >10 | 2/12 (17%) | 3/21 (14%) | 4/28 (14%) | 5/38 (13%) | 5/41 (12%) | 23/82 (28%) | 28/91 (31%) | 31/94 (33%) | |
| ≤6 | 4/110 (4%) | 10/179 (6%) | 11/208 (5%) | 15/241 (6%) | 19/273 (7%) | 45/366 (12%) | 48/373 (13%) | 51/377 (14%) | |