Table 1.
Patient number | Age | Sex | AML subtype | Cytogenetics | Treatment | Aplastic (day 14) | Reinduction | Complete remission (4–6 weeks) | Clinical response |
---|---|---|---|---|---|---|---|---|---|
1 | 67 | M | M4 | 46 X, Y | Ida + Ara-C | Yes | No | Yes | CR |
2 | 47 | F | M2 | 46 X, X | Ida + Ara-C | Yes | No | No | RD |
3 | 55 | M | MLD | 46 X, Y | Ida + Ara-C | Yes | No | Yes | CR |
4 | 47 | M | M7 | Complex | Ida + Ara-C | No | Yes | Yes | CR |
5 | 20 | M | M1 | 46 X, Y | Ida + Ara-C | No | Yes | No | RD |
6 | 59 | M | MLD | 46 X, Y | Ida + Ara-C | Yes | No | Yes | CR |
7 | 70 | F | M4 | 46 X, X −7, + 21 | MY-FLAI | No | Noa | No | RD |
8 | 19 | M | MLD | 46 X, Y | Ida + Ara-C | No | Yes | Yes | CR |
MLD: multilineage dysplasia, Ida + Ara-C: idarubicin + cytarabine, MY-FLAI: fludarabine, idarubicin, cytarabine, gemtuzumab ozogamicin.
Patient 7 did not receive a second induction due to resistant disease (49% blasts in a hypercellular marrow) found on the day 14 bone marrow biopsy and other comorbidities.