Table 3.
Fitness analysis of genotypic changes
| No. of descendent genotypes | No. of genetic events
|
|
|---|---|---|
| ≥1 (success) | 0 (failure) | |
| tbpB family 1 | 1 | 18 |
| tbpB family 3 | 0 | 3 |
| tbpB family 4 | 3 | 3 |
| pgm | 1 | 1 |
| IS1106A | 5 | 4 |
| Translocation of opaJ | 2 | 8 |
| Translocation of opaA | 1 | 4 |
| Other opa changes | 4 | 5 |
| iga | 1 | 1 |
Note: P = 0.01 for the null hypothesis of randomness according to a χ2 test by comparing success of tbpB family 1 with all other genotypic changes (clump test 3; 100,000 repeats; ref. 21). The null hypothesis was also rejected when changes at opa alleles were categorized into replacement of opaB (5 successes; 10 failures) or opaD (2 successes; 7 failures).