Table 2.

Levels of N²-ethylidene-dGuo (fmol/μmol dGuo) in oral cell DNA before and after each dose of alcohol. Levels of N²-ethylidene-dGuo (as N²-ethyl-dGuo) were measured in oral cell DNA from each subject (from 1 to 10). The first row reports participants’ adduct levels measured one week before the first dose was given. This is the point at which participants began to abstain from consumption of any alcoholic beverage other than the dose given for the study. “Baseline” levels of N²-ethyl-dGuo were also measured 1 h before each dose was given. The rows that follow report the levels of N²-ethyl-dGuo at the various time points after consumption of the three increasing doses (from dose 1 to dose 3).

	subject	1	2	3	4	5	6	7	8	9	10
												mean	SD
	1 week before the dose	2581	2769	1427	4047	2856	1256	1650	1661	1532	8034	2781	2041
dose 1	baseline	2795	2364	1503	684	4892	2757	1476	1052	4195	3382	2510	1374
	2 hours	6149	1793	3501	1266	13420	2433	6850	10100	6378	8570	6046	3922
	4 hours	7768	10900	8122	1458	5673	6467	2420	15919	6136	10630	7549	4233
	6 hours	1737	1690	1824	2844	2541	2199	1911	1610	5355	5807	2752	1545
	24 hours	4168	1672	2018	1236	2541	1362	1606	871	2789	4436	2270	1218
	48 hours	5137	1087	4776	971	2362	1423	2006	5556	1744	8203	3326	2438
	120 hours	4464	2664	2154	780	3389	2157	3792	815	1271	3394	2488	1277
dose 2	baseline	-a	1666	1803	1855	-	2328	1657	2684	1108	1043	1768	554
	2 hours	-	3787	2623	4591	-	32230	16090	35330	8094	8841	13950	12960
	4 hours	-	9532	1533	7570	-	8323	2840	86630	22040	1479	17490	28720
	6 hours	-	3693	935	4195	-	2782	1960	3551	2969	10500	3823	2889
	24 hours	-	1631	1710	1973	-	1867	1780	2271	15650	2896	3722	4837
	48 hours	-	1598	419	2535	-	3264	2072	1461	2176	1582	1888	841
	120 hours	-	1717	3738	628	-	1022	1902	1987	2959	762	1839	1082
dose 3	baseline	1466	1108	2019	1417	1338	242	2341	443	1546	1039	1296	638
	2 hours	13610	4935	32440	5071	31890	9003	10610	43430	33090	-	20450	14640
	4 hours	12260	17300	18360	4875	14230	7273	6338	11990	28860	39890	16140	10900
	6 hours	-	452	15100	3668	831	859	1047	3723	20470	4397	5616	7181
	24 hours	551	461	11270	1634	240	316	754	872	2028	1469	1960	3326
	48 hours	1815	1420	3084	2201	853	1679	538	1118	1021	-	1525	779
	120 hours	10020	369	861	1706	494	361	1093	186	1124	1156	1737	2948
	168 hours	791	318	608	4087	361	264	600	326	426	-	865	1221

^aValues missing due to poor recovery of N²-ethyl-dGuo.