Table 3.
Variation of peak/baseline ratio and peak/next baseline ratio after increasing doses of alcohol.
| Dose 1 | Dose 2 | Dose 3 | p for trend | |
|---|---|---|---|---|
| Peak/Baselinea Mean (95% CI) | 3.8 (2.4, 5.9) | 8.6 (3.8, 19.3) | 17.5 (8.5, 35.9) | p = 0.001 |
| Peak timing (h) b Mean (SD) | 3.6 (1.3) | 3.5 (1.4) | 2.4 (0.8) | |
| Peak/Next Baseline c Mean (95% CI) | 4.5 (2.8, 7.4) | 14.1 (3.5, 56.7) | 31.9 (10.9, 93.6) | p < 0.001 |
The ratio between the average maximum N2-ethyl-dGuo level reached after each dose of alcohol and the average baseline level of for that dose was calculated and a 95% confidence interval for the ratio was formed.
The average time at which the maximum N2-ethyl-dGuo was reached after each dose was calculated.
To determine whether the levels of N2-ethyl-dGuo returned to baseline after reaching a peak, the ratio between the average maximum N2-ethyl-dGuo level reached after each alcohol dose and the average baseline DNA adduct level measured for the next alcohol dose was calculated. The final N2-ethyl-dGuo level measured at 168h was used as next baseline level for the third alcohol dose.