Table 1.

Baseline characteristics of the study subjects (n=488)

Variable	Value (All subjects n=488)	Placebo (n=1(n=123)	HTa+Calcitriolb (n=122)	HT (n=120)	Calcitriol (n=123)	P valuec
Age in years:mean (SDd)	71.4(±3.5)	71.1(±3.7)	71.4(±3.6)	71.4(±3.6)	71.8(±3.4)	0.536
BMI (kg/m2):mean (SD)	27.0(±4.8)	27.22 (±5.0)	26.7(±4.3)	27.5 (±4.6)	26.7(±5.4)	0.541
Education (n):
Minimum	57	14	12	13	18	0.674
More than minimum	431	109	110	107	105
Living (n):
Living alone	189	43	47	50	49	0.744
Lining with others	299	80	75	70	74
Hypothyroidism (n):
No	399	100	98	99	102	0.952
Yes	89	23	24	21	21
Antidepressant use (n):
No	469	117	119	115	118	0.796
Yes	19	06	03	05	05
Smoking (n):
No	430	108	108	103	111	0.763
Yes	58	15	14	17	12
Alcohol (n):
No	325	83	84	81	77	0.741
Yes	163	40	38	39	46
Baseline Depression (n)	57	17	10	18	12	0.295
Baseline GDSe Score: mean (SD)	4.8 (±4.6)	4.6(±4.5)	4.3(±4.2)	6.0(±5.0)	4.5(±4.5)	0.022
Final GDS Score: mean (SD)	4.2(±4.2)	4.0(±4.0)	4.0(±4.4)	5.1(±4.4)	3.9(±3.9)	0.100
Baseline serum 25-hydroxyvitamin -D, mean (SD), ng/ml	31.3(±10.5)	31.7(±11.0)	32.0(±11.6)	30.9(±9.9)	30.6(±9.4)	0.694
Serum total estradiol (pg/ml): mean (SD)	11.95(±5.07)	12.23(±5.23)	11.27(±4.55)	11.54(±4.72)	12.76(±5.63)	0.155
Serum SHBG (nmol/liter): mean (SD)	147.47(±67.7)	142.78(±66.3)	159.53(±74.5)	142.27(±65.5)	145.74(±63.7)	0.235
Serum total testosterone, mean (SD), ng/ml	0.23(±0.11)	0.23(±0.11)	0.23(±0.11)	0.24(±0.10)	0.24(±0.12)	0.688
XbaIf(n=337)
xx	132	33	29	36	34	0.212
Xx	157	41	43	40	33
XX	48	20	7	9	12
PvuIIg(n=338)
pp	96	26	25	20	25	0.675
Pp	171	45	40	49	37
PP	71	24	14	16	17
BsmIh(n=362)
bb	141	44	33	32	32	0.898
Bb	169	46	40	42	41
BB	52	12	11	16	13
TaqIi(n=362)
tt	51	12	10	16	13	0.774
Tt	171	45	41	43	42
TT	140	45	33	31	31

^aHormone Therapy with conjugated equine estrogens 0.625 mg/daily in hysterectomized women or combined with medroxyprogesterone acetate 2.5 mg/daily in women with intact uterus

^bCalcitriol 0.25g twice a day

^cOne-way ANOVA was used for comparing continuous variables and Chi-square test for categorical variables

^dStandard deviation

^eGeriatric Depression Screening score

^f,gEstrogen receptor -alpha single nucleotide polymorphisms-numbers indicate frequencies

^h,iVitamin D receptor single nucleotide polymorphisms- numbers indicate frequencies