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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Hepatology. 2012 Feb 9;55(4):1070–1082. doi: 10.1002/hep.24783

Figure 4. Deletion of CrebH leads to impaired FA metabolism and profound NASH in the mice under the AHF diet.

Figure 4

(A) Lipidomic analysis of eicosanoids and docosanoids in the liver tissues of the CrebH null and wild-type control mice after the AHF diet for 6 months. Levels of lipid metabolites that were decreased or increased in the CrebH null liver, compared to that in the wild-type control liver (P-value cutoff was <0.05), were shown. Each bar denotes the mean ± SEM (n=4 mice per group). (B) Histological examination (hematoxylin eosion staining) of liver tissue sections of the CrebH null and wild-type mice after the AHF diet for 6 months (magnification: 200x). (C) Sirius staining of collagen deposition in the liver tissue of the wild-type and CrebH null mice after the AHF diet (magnification: 200x). (D) Histological scoring for NASH activities in the livers of the CrebH null and wild-type mice after the AHF diet for 6 months. The Grade scores were calculated based on the scores of steatosis, hepatocyte ballooning, lobular and portal inflammation, and Mallory bodies. The Stage scores were based on the liver fibrosis. Mean ± SEM (n=4) values are shown. P-values were calculated by Mann-Whitney U-test.