Table 1.
Comparison of IC50 values determined via the coupled enzyme assay described here and measured using a spectrophotometric assay for phosphate releasing enzymes method. Error in the table represents the standard deviation for three independent experiments.
| Compound | IC50 (µM) | Previously Reported IC50 (µM) |
|---|---|---|
| Zoledronate | 0.7 ± 0.3 | 1.1a |
| Risedronate | 0.7 ± 0.2 | 2.5 b |
| Alendronate | 11 ± 7 | 26b |
a
From Leon et al. [11]. No IPP or GPP concentrations were included therein.
b
Eric Oldfield, personal communication.