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. Author manuscript; available in PMC: 2012 Apr 4.

Published in final edited form as: Gastroenterology. 2008 Jun 4;135(3):926–936.e2. doi: 10.1053/j.gastro.2008.05.079

Panel A plots the averaged gastrointestinal transit distribution histograms using FITC-dextran measured in control Egr-1^+/+ and Egr-1^−/− mice (open and gray bars). Twenty-four hours after surgical manipulation (SM) a delay was observed in the gastrointestinal transit of Egr-^+/+ mice (solid bars), but not in Egr-1^−/− mice (cross-hatched bars) (st=stomach, sb=small bowel, cm=cecum, c=colon). Panel B: Calculated geometric centers from the transit distribution histograms for the four groups of mice. Panel C: Graph of bethanechol-stimulated dose-response curves for jejunal circular muscle strips obtained from control and manipulated, Egr-1^+/+ and Egr-1^−/− mice. Control dose-response curves to increasing concentrations of bethanechol were similar between Egr-1^+/+ (● closed circles) and Egr-1^−/− (○ open circles) mice. Twenty-four hours after surgical manipulation muscle strip contractions were diminished in Egr-1^+/+ (■ closed square), but not in Egr-1^−/− (□ open squares) mice. Data are expressed as mean ± SEM (N=5).

Panel A plots the averaged gastrointestinal transit distribution histograms using FITC-dextran measured in control Egr-1^+/+ and Egr-1^−/− mice (open and gray bars). Twenty-four hours after surgical manipulation (SM) a delay was observed in the gastrointestinal transit of Egr-^+/+ mice (solid bars), but not in Egr-1^−/− mice (cross-hatched bars) (st=stomach, sb=small bowel, cm=cecum, c=colon). Panel B: Calculated geometric centers from the transit distribution histograms for the four groups of mice. Panel C: Graph of bethanechol-stimulated dose-response curves for jejunal circular muscle strips obtained from control and manipulated, Egr-1^+/+ and Egr-1^−/− mice. Control dose-response curves to increasing concentrations of bethanechol were similar between Egr-1^+/+ (● closed circles) and Egr-1^−/− (○ open circles) mice. Twenty-four hours after surgical manipulation muscle strip contractions were diminished in Egr-1^+/+ (■ closed square), but not in Egr-1^−/− (□ open squares) mice. Data are expressed as mean ± SEM (N=5).