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. Author manuscript; available in PMC: 2012 May 12.
Published in final edited form as: Neuron. 2011 May 12;70(3):410–426. doi: 10.1016/j.neuron.2011.04.009

Figure 2. Endogenous Tau Exists in Dendrites.

Figure 2

Tau immunoprecipitates with PSD95, a postsynaptic protein, and regulates the association of PSD-95 with NMDAR subunits and the tyrosine kinase Fyn. Overexpression of a human N-terminal truncation of tau (Δtau74, light grey) or knocking out tau (tau−/−, dark grey) reduced the amount of NR1, NR2a, NR2b, and Fyn within PSD95 complexes. From Ittner et al., 2010 with permission.