Figure 3. Tau Reduction Suppresses Drug-induced Seizures in Mice and Neuronal Bursting Activity in Acute Hippocampal Slices.

A) Partial or complete reduction of tau in mice without hAPP expression delayed the onset and reduced the severity of seizures induced by pentylenetetrazol, a GABA_A receptor antagonist (Roberson et al., 2007). B) Tau knockout reduced aberrant neuronal discharges in acute hippocampal slices after disinhibition with the GABA_A receptor antagonist bicuculline, as illustrated by measurements of the coastline burst index (Roberson et al., 2011). NTG, no hAPP expression; hAPPJ20, hAPP mice from line J20