Table 3. Electrophysiological Abnormalities of hAPP-J20 Mice Prevented by Tau Knockout.

(Roberson et al., 2011).Similar results were observed after exposure of hippocampal slices to recombinant Aβ aggregates (Shipton et al., 2011).

Electrophysiological Measure*	Tau−/− Mice**	hAPP/Tau+/+ Mice**	hAPP/Tau−/− Mice***
Action Potential-driven	Normal	↓	Normal
IPSC Frequency
Coastline Burst Index	↓	↑	↓
EEG epileptiform activity (cortex)	Normal	↑	Normal
eEPSC Amplitude	Normal	↑	Normal
eIPSC Amplitude	Normal	↓	Normal
Long-term Potentiation	Normal	↓	Normal
mEPSC Frequency	Normal	↓	Normal
mIPSC Frequency	Normal	↑	Normal
NMDAR/AMPAR Ratio	Normal	↓	Normal
Paired Pulse Ratio	Normal	↓	Normal
sIPSC Frequency	↑	↓	↑
Synaptic Strength (CA1)	Normal		Normal

EPSC, excitatory post-synaptic current; IPSC, inhibitory post-synaptic current; e, evoked; m, miniature; s, spontaneous

^*Recorded at perforant path togranule cell synapsein dentate gyrusunless indicated otherwise. All recordings were obtained in acute hippocampal slices.

^**Relative to Tau^+/+ mice

^***Relative to hAPP/Tau^+/+ mice