Figure 6. Retinal neuroprotection in AQP4 deficiency in a transient ischemia-reperfusion model.
A. Hematoxylin and eosin-stained retinal sections before and at 12 and 96 hours after 60 min retinal ischemia in wildtype and AQP4 null mice. Note retinal swelling at 12 h and degeneration at 96 h. B. Functional analysis by electroretinography. Representative electroretinograms before and at 1, 2 and 4 days after 45 min retinal ischemia. Adapted from Da and Verkman (2004).