Table 1.

Subject characteristics and their relationship to plasma Aβ1-40 and Aβ1-42: HAAS Aβ sub-study

Characteristics*	Study sample	Aβ1-40†	Aβ1-42†
	N=667	Beta (SE)‡	Beta (SE)‡
Age at exam 3, years	58.9 (4.4)	0.086 (0.04)§	0.016 (0.04)
Age at event, years	83.0 (4.4)	−0.018 (0.06)	0.014 (0.06)
Aβ draw to event, years	15.8 (3.1)	−0.010 (0.04)	−0.002 (0.04)
Education, years	10.6 (3.2)	0.002 (0.04)	0.044 (0.04)
Stroke, n (%)	45 (7)	0.196 (0.15)ll	0.141 (0.15)ll
Diabetes, n (%)	279 (41)	0.096 (0.08)ll	0.132 (0.08)ll
ApoE genotype, n (%)
33	455 (68)	0.038 (0.05)#	0.038 (0.05)#
22 or 23	53 (8)	−0.075 (0.14)ll	0.056 (0.14)ll
34 or 44	125 (19)	−0.130 (0.10)ll	−0.208 (0.10)ll
Missing value	34 (5)	−0.144 (0.18)ll	−0.076 (0.18)ll
Dementia, n (%)
Total	77 (12)	−0.121 (0.12)ll	−0.101 (0.13)ll
All AD	53 (8)	−0.236 (0.15)ll	−0.216 (0.15)ll
Pure AD	38 (6)	−0.359 (0.17)§ll	−0.302 (0.17)ll
VaD	24 (4)	0.137 (0.21)ll	0.152 (0.21)ll
Blood pressure, mmHg
SBP	132.7 (16.7)	0.081 (0.04)§	0.111 (0.04)§
DBP	83.1 (9.5)	0.058 (0.04)	0.107 (0,04)§
Pulse pressure	49.6 (11.0)	0.074 (0.04)	0.077 (0.04)§
Lipid at exam 1, mg/dL
Triglycerides	295.3 (269.4)	0.074 (0.04)**	−0.049 (0.04)**
Cholesterol	236.3 (44.5)	0.066 (0.04)	0.077 (0.04)§

^*Mean (SD) unless otherwise indicated;

^†log-transformed and standardized;

^‡adjusted for age at exam 3, beta for 1 standard deviation increase;

^§p ≤ 0.05;

^lladjusted difference with reference;

^#adjusted mean;

^**triglycerides are log-transformed and standardized for computation of beta.

SBP = systolic blood pressure; DBP = diastolic blood pressure; event includes death, dementia or end of follow-up.