TABLE I.
Summary of characteristics of HSCT patients receiving transplant for sickle cell disease or thalassemiaa
| Disease | Age (yrs) |
Gender | Blackb | Hispanic | Allogeneic HSCT Type |
Myeloablative Prep |
Max aGVHD grade through 3m |
Max cGVHD grade through 12m |
Max organ toxicity through 3m |
|---|---|---|---|---|---|---|---|---|---|
| SCD | 6 | F | Yes | No | Related | No | 0 | 0 | Good |
| SCD | 7 | M | Yes | No | Related | Yes | 0 | 1 | Good |
| SCD | 7 | M | Yes | No | Unrelated | Yes | 0 | 0 | Good |
| SCD | 10 | M | No | No | Related | Yes | 0 | 0 | Good |
| SCD | 13 | M | Yes | No | Related | Yes | 0 | 0 | Good |
| SCD | 17 | F | Yes | No | Related | No | 0 | 0 | Good |
| SCD | 18 | M | Yes | No | Unrelated | No | 2 | 2 | Good |
| Thal | 5 | M | NSd | No | Related | Yes | 0 | 0 | Good |
| Thal | 7 | F | No | No | Related | Yes | 1 | 0 | Good |
| Thal | 7 | M | No | No | Related | No | 2 | 0 | Good |
| Thal | 8 | M | No | No | Related | Yes | 0 | 0 | Good |
| Thal c | 8 | F | NSd | Yes | Unrelated | Yes | 4 | 2; progressive onset |
Intermediate to poor |
| Thal | 13 | F | No | No | Unrelated | No | 1 | 0 | Good |
a
SCD=sickle cell disease; Thal=thalassemia; M=male; F=female; aGVHD=acute graft versus host disease; cGVHD=chronic graft versus host disease;
b
Child race per parent report;
c
Patient died approx. 3 months after transplant;
d
Not specified