Fig. 6.
Effects of saturated and unsaturated diets on ileum tight junction protein and protein-adaptor mRNA levels in response to chronic alcohol feeding. USF diet significantly down-regulated mRNA levels of (A) ileum tight junction proteins and (B) protein-adaptors compared to SF diet. EtOH supplemented to the USF diet resulted in further suppression of these proteins. Intestinal tight junction protein mRNA expression was assessed by RT-PCR. The relative mRNA levels were analyzed using 2-ΔΔCt method by normalizing with 18s mRNA expression. Results are presented as fold changes over SF group set as 1. Values are mean+SEM, n=6 animals/per group, *p <0.05, one-way ANOVA with Tukey’s post hoc test.