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. 2012 Apr;11(3):291–302. doi: 10.1111/j.1601-183X.2012.00766.x

Figure 8. MC3R agonist increases the number of pERK-IR neurons in the DMH.

Figure 8

pERK-IR neurons in the DMH (a and b), VMN (d and e) and ARC (g and h) in control B6 mice treated with Acsf (a, d and g) or 1 nmol d-Trp(8)-γMSH (b, e and h) fed ad libitum or after an overnight fast. The representative photomicrographs were taken using sections collected from mice treated in fed conditions. Treatment with d-Trp(8)-γMSH significantly increased the number of pERK-IR neurons in the DMH in fed (representative photomicrograph at bregma level: −1.82 mm), but not fasting conditions (c). In the VMN, d-Trp(8)-γMSH significantly reduced the number of pERK neurons (f) in fed, but not fasting conditions (representative photomicrograph at bregma level: −1.58 mm). There was no effect of treatment in the ARC (i) (representative photomicrograph at bregma level: −1.58 mm). *P < 0.05 vs. Acsf.**