Table 5. Gene expression in cardiac tissue.
Cardiac Gene Expression | |
Diabetic | |
TGFβ | 1.82±0.40 (n = 5) |
MCP-1 | 2.11±0.84 (n = 5) |
IL1β | 1.01±.25 (n = 5) |
TNFα | 0.58±0.16 (n = 5) |
CTGF | 4.05±0.88 (n = 5)* |
Fibronectin | 1.54±0.24 (n = 5) |
Cardiac gene expression at 10 weeks of age; mRNA levels in diabetic mice relative to controls (assigned as 1.0) normalized to β-actin mRNA level. Values are means ± SE; n, number of mice; TGFβ, transforming growth factorβ; MCP-1, monocyte chemoatactic protein-1; IL1β, interleukin 1β; TNFα, tumor necrosis factor-α; CTGF, connective tissue growth factor.
P = 0.001 between diabetic and control animals.