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A) Systemic response parameter ‘body temperature’ during 72 h after targeting different doses of LPS either to the airways (closed symbols) or to the alveoli (open symbols). B) Increase of 12 h - body temperature with increasing LPS dose targeted to the airways in comparison to 5 µg LPS targeted to the alveoli (open symbol). Data represent mean +/− SD (n = 7; *: p<0.05, **: p<0.01 compared to baseline; ++: p<0.01 for 5 µg alveolar compared to 5 µg airway LPS).
