Figure 3. Variations of CD34, DNTT and Vpreβ1 transcript expressions.

Fold-change increase of transcripts for CD34, terminal deoxynucleotidyltransferase (DNTT), expressed by lymphoid precursors, and V pre-B lymphocyte gene 1 (Vpreβ1), a part of the pre-B cell receptor in the patient who developed PML (pmlMS; black circles) and natalizumab-treated patients (nMS; white circles) were represented at the indicated time points. Bars indicate medians and error bars indicate the 25^th and 75^th percentile. Data were calculated with the ΔΔCt method using the value obtained with pre-therapy samples (T0) as the calibrator for each patient.