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. 2012 Apr 4;7(4):e34493. doi: 10.1371/journal.pone.0034493

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Sottini et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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IgG, IgA, and IgM concentration was analyzed at the indicated time points in the sera of the patient who developed PML (pmlMS; black bars) and patients treated with natalizumab (nMS; white bars). Bar height represents the mean value and error bars represent the 95% confidence interval of the mean. * Measures of the pmlMS patient that were outside the 95% confidence interval of the means found in nMS. Dashed lines represent the lowest limit of the laboratory reference interval for healthy subjects.