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. 2012 Apr 4;7(4):e35024. doi: 10.1371/journal.pone.0035024

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Lethbridge et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Acute effect of isoproterenol on MC spiking. A1 . Single MC spiking patterns in the control condition and in the presence of ISO bath application. Arrow indicates the time of the single olfactory nerve test stimulus. A2&A3 . Peristimulus spike frequency histograms (binning 50 ms) under the control condition (red), in the presence of ISO (black) of the example cell in A1 (A2); and of the average of n = 7 cells in the same condition (A3). A4 . Histogram comparing mean spike frequencies during the 250 ms intervals before (spontaneous) and after the olfactory nerve stimulation (evoked) under control conditions (red) and during ISO application (black). B1-B3 . Local puff of the GABAA receptor agonist muscimol (0.2–10 µM) to the glomerular layer adjacent to the stimulation pipette during TBS blocked ISO+TBS induced MC spike potentiation. B1 . Single MC spiking patterns before, and 30 min following, TBS induction in the presence of ISO and local muscimol application. B2&B3 . Peristimulus spike frequency histograms under the control condition and 20–30 min after TBS induction in the presence of ISO and muscimol of the example cell in B1 (B2); and of the average of n = 6 cells (B3). C. Histogram comparing mean spike frequencies during the 250 ms intervals before (spontaneous) and after olfactory nerve stimulation (evoked) under control conditions (red) and 20–30 min post-inductions (black). *p<0.05. Error bars, mean±SEM.