Table 1. Classification of chitosan-regulated genes in the stomach by KEGG pathways.
| KEGG pathway | Stomach | |
| Observed (total)a | p valueb | |
| Oxidative phosphorylation | 38 (108) | 8.75×10−11 |
| Ribosome | 20 (80) | 2.17×10−8 |
| Cell communication | 21 (109) | 6.11×10−5 |
| IL6 signaling pathway | 4 (29) | 0.0037 |
| Pyruvate metabolism | 11 (37) | 0.0040 |
| GnRH signaling pathway | 14 (90) | 0.0105 |
| TNF-α signaling pathway | 3 (34) | 0.0105 |
| Glycolysis/Gluconeogenesis | 14 (53) | 0.0107 |
| Benzoate degradation | 2 (7) | 0.0215 |
| Glycerolipid metabolism | 9 (46) | 0.0215 |
| IFNγ signaling pathway | 11 (65) | 0.0215 |
| LPS signaling pathway | 11 (66) | 0.0215 |
| Ether lipid metabolism | 6 (29) | 0.0249 |
| Wnt signaling pathway | 14 (144) | 0.0325 |
| Glutathione metabolism | 9 (41) | 0.0363 |
| IL12 signaling pathway | 4 (26) | 0.0476 |
| Insulin signaling pathway | 8 (91) | 0.0476 |
a
“Observed" means the number of genes regulated by chitosan in this pathway. “Total" means the total number of genes in this pathway.
b
p-Value was calculated on WebGestalt web site (http://bioinfo.vanderbilt.edu/webgestalt/login.php) by hypergeometric test.