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. Author manuscript; available in PMC: 2013 Apr 23.
Published in final edited form as: Brain Res. 2012 Feb 24;1450:138–147. doi: 10.1016/j.brainres.2012.02.041

Figure 2. The levels of water-soluble and triton-soluble Aβ are elevated in dementia.

Figure 2

Average quantifiable Aβ monomer (A, C, E) and Aβ dimer (B, D, F) detected in duplicate AW7 IPs from 28 samples analysed by western blot with 2G3/21F12 are shown. Cases are separated into three groups: 1) non-demented (CDR 0 and 0*), 2) mildly demented (CDR 0.5 and 1) and 3) severely demented (CDR 2/3). CDR 0* cases were not demented but had significant amyloid pathology and are highlighted with red circles. The levels of quantifiable Aβ are indicated on the vertical discontinuous y-axis. Horizontal lines indicate the mean value detected for each group. * indicates significant difference (p < 0.05), while NS indicate no significant difference. Detectable levels of Aβ are indicated in black and samples in which Aβ was not detected are shown in red. CDR 0, n=6; CDR 0*, n=3; CDR 0.5, n= 6; CDR 1, n= 5 and CDR 2/3, n= 8.

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